EP 2 707 383 B1 relates to methods of preventing and eliminating the formation of trisulfide bonds in proteins during protein production.
Claim 1 reads:
Use of an inhibitor of cysteine degradation for reducing the formation of trisulfide bonds in proteins, ……. and wherein the use comprises: culturing cells expressing said proteins in the presence of an effective amount of the inhibitor of cysteine degradation,