EP 3 264 891 A1, filed as PCT application PCT/US2016/020768 relates to Etv2 genes and uses thereof.
The application concerns the generation of pig-human chimeric animals with the aim of using them as a source of human vasculature and blood.
The chimeric pigs are obtained by methods involving “blastocyst complementation“. This involves creating a non-human (host) blastocyst lacking one or more genes involved in the development of the cells of interest.